These observations suggested that generation or gene transfer of BCR::ABL1 fusion in human myeloid leukemia cell lines may affect gene expression involved in signal transduction and transcriptional regulation, which are upregulated in Ph-positive myeloid leukemia cell lines and CML patients’ samples, at least in part. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.