HOXB2 and acute myeloid leukemia: We also performed principal component analysis using the 16 genes upregulated by retroviral gene transfer of p210 BCR::ABL1 fusion in HL-60 [67], an acute myeloid leukemia cell line, which includes PIM1 oncogene, a signaling kinase (a guanine nucleotide exchange factor and Ras homolog) [68], RAPGEF2, a member of the RAS subfamily of GTPases that function in signal transduction [69], HOXB2, SOX5, and KLF1, transcription factors, and GAGE antigens, a family of cell surface antigens originally identified in melanoma cells.