Ataxia-telangiectasia mutated (ATM), Rad3-related protein (ATR), and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) belong to the phosphatidylinositol 3-kinase-related kinases (PIKKs) family and coordinate DNA repair process and cell cycle progression to preserve genomic stability against tumorigenesis and tumour progression [13]. The gene discussed is PRKDC; the disease is neoplasm.