We found that CHK2T68D, a pCHK2T68 mimic (but not CHK2D347A, a kinase-dead mutant) accelerated oxaliplatin-induced DNA damage repair, enhanced the CHK2/PARP1 interaction, and promoted cell colony formation and xenograft CRC growth in the presence of oxaliplatin. Here, PARP1 is linked to colorectal carcinoma.