In the case of BMW transport, the metastatic colonization might be achieved through polarization of cancer cells through the exit phase of blebbishield emergency program93,100 where calcium signaling and VEGF mediates polarization possibly through re-expression of c-Myc.18 In the case of BMW transport, the metastatic target selection molecules are mostly homing signals of the immune cell fusion partner. Here, MYC is linked to cancer.