Cellular transformation (acquiring spheroid structure with EMT-like poorly or less differentiated/polarized state) and accumulation of genomic instability (numeric and structural) are required for tumorigenesis and metastasis of cancer cells, and K-Ras/MAPK signaling emerges as a central driver of these pivotal events19,93,104 (where the contribution of other oncogenes such as Src, Myc, H-Ras, N-Ras, and others also play a role depending on cellular/tissue type context-dependent manner). The gene discussed is MYC; the disease is cancer.