Platelet-derived autotaxin interaction with αvβ3 integrins on cancer cells directs bone metastasis.226 More interestingly, osteogenic cells supply calcium to cancer cells through gap junctions and promote bone micrometastasis.227 In brain metastasis of breast cancer cells, a combination of high cholesterol and low triacylglycerols (TAGs) were found. Here, ENPP2 is linked to cancer.