The apoptotic cells have more advantage than mitotic cells towards metastasis because apoptosis unleashes the IRES emergency translation during the reversal of apoptosis (Fig. 2)19,24, which can be utilized by the apoptotic cells to translate VEGF (to drive blebbishield emergency program), c-Myc/N-Myc (to drive glycolysis and metastasis), and c-IAPs such as c-IAP-1/2, XIAP (to block death signaling and caspase-3).19,100 The apoptotic event prepares the cancer cells for drug resistance, stemness, and metastasis. The gene discussed is VEGFA; the disease is cancer.