In cells that undergo MET during metastatic colonization, a transcriptional program of c-Myc is pivotal as it promotes E-cadherin expression.24 Often, a mere expression of E-cadherin in the cell may not be sufficient because the ascites-derived bladder cancer cells have distinct population of cells with internal E-cadherin expression but has impaired surface E-cadherin expression behave inferior in tumor aggressiveness.220. Here, CDH1 is linked to urinary bladder carcinoma.