Two of the 16 genes (PPARG, PLIN1) were causative genes for familial partial lipodystrophies (FPLDs), which are Mendelian forms of extreme fat distribution (Supplementary Data 7; fold-enrichment, 554; 95% confidence interval [CI], 49 to 3623; Fisher’s exact test p = 1.3 × 10−5). The gene discussed is PLIN1; the disease is partial lipodystrophy.