Rare pLOF variants in INHBE were associated with lower alanine transaminase levels (ALT), a measure of liver injury, lower corrected T1 (cT1, an MRI imaging measure of liver inflammation/fibrosis) and lower nonalcoholic fatty liver disease (NAFLD) activity score at liver biopsy in bariatric patients (Supplementary Data 19), though the latter association is driven by only three heterozygous carriers in the bariatric surgery cohort and should be interpreted with caution. This evidence concerns the gene INHBE and metabolic dysfunction-associated steatotic liver disease.