PPARG and type 2 diabetes mellitus: PPARG mutation carriers had 0.46 SD higher BMI-adjusted WHR (IVW meta-analysis p = 0.012; Table 2, Supplementary Data 23) and >4-fold higher odds of type 2 diabetes (IVW meta-analysis p = 3.4 × 10−4; Table 2, Supplementary Data 23) compared to noncarriers; which is consistent with the effect-size of other Mendelian mutations in population-based studies22,40,41.