Notably, in addition to these treatment effects in the targeted tumor, we also found increased abundance of central memory T cells (CD44+CD62L+), CD44+ effector T cells and CD69+ activated T cells among CD4+ and CD8+ T cells in the TDLNs in PIC + RT group (Fig. 4p and Supplementary Figs. 26, 27)45. The gene discussed is CD8A; the disease is neoplasm.