CD8A and neoplasm: Given the favorable inflammatory and functional effects we observed from the multifunctional PIC in enhancing tumor cell sensitivity to RT, increasing the activation of an IFN-I response by RT, increasing tumor cell infiltration and antigen presentation by DCs, limiting the M2 polarization of macrophages by RT, and augmenting CD8+ T cell infiltration of tumor, we examined the potential therapeutic interaction between RT and PIC in vivo.