CD4 and neoplasm: By analyzing markers of activation state (CD69), effector state (CD44) and memory state (CD62L) on tumor infiltrating T cells, we found higher abundance of activated T cells (CD69+CD4+ and CD69+CD8+ cells), effector T cells (CD44+CD4+ and CD44+CD8+ cells) and effector memory T cells (CD44+CD62L−CD4+ and CD44+CD62L−CD8+) out of CD45+CD3+ T cells among the PIC + RT treated tumors compared to other groups (Fig. 4l, m and Supplementary Fig. 24).