Fib_1 expressed a wealth of growth factors for tumor cells, such as HGF, FGF7, and BDNF (Fig. 8a), in agreement with other studies wherein the HGF-MET and FGF7-FGFR4 axes were shown to be promising therapeutic targets for GC and other tumors51,52. The gene discussed is FGFR4; the disease is gastric cancer.