EBV circBART2.2 binds RIG-I and modulates the immune response leading to chronic inflammation, a tumour permissive microenvironment, and viral replication [14,17].EBV circBART2.2 binds to the helicase domain of RIG-I and activates transcription factors NF-κB and IRF3 [14]. The gene discussed is RIGI; the disease is neoplasm.