Finally, PTF1A showed direct binding to genes encoding regulators of cell adhesion, migration, and morphogenesis including KIRREL2, ITGB1, SLIT3, RHOV, SEMA3C, CTNNA2, and CTNND1, encoding p120 catenin (Figures 4J, S4I, and S4J), and also targeted several T2D susceptibility loci that showed reduced activity in mouse and human knockout models (STARD10, TCF7L2, and CDKAL1; Table S4). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.