Viral knockdown of Dnmt3a induced the same anxiety-like phenotype previously observed in CSDS mice as measured by the elevated plus maze (EPM) test, while Dnmt3a1 viral overexpression in mouse dorsal mPFC, which regulates fear, anxiety, risk taking, and decision-making, rescued CSDS-induced anxiety (Chocyk et al., 2013; Elliott et al., 2016). Here, DNMT3A is linked to Anxiety.