NR3C1 and generalized anxiety disorder: In consensus with increased methylation studies of NR3C1, hypermethylation of exon 1F at several CpG sites correlated with a decrease in the mRNA levels of GRα (one isoform of glucocorticoid receptor) in samples of peripheral blood mononuclear cells (PBMCs) of adults diagnosed with generalized AD (GAD; Wang et al., 2017).