DNMT1 and Anxiety: In a previous study, Low Novelty-Responding (bLR) rats, bred to exhibit increased anxiety and depressive-like behaviors, displayed decreased mRNA levels of Dnmt1 in the dentate gyrus (DG) and CA3 of the hippocampus, compared with their High Novelty-Responding (bHR) counterparts (Simmons et al., 2012).