CRHR1 and neuroblastoma: Overexpression of YY1 in mouse neuroblastoma cells (N2a) was shown to enhance CRHR expression by increased promoter activity, suggesting that increased methylation at CpG1 of Crhr1 in LAB-CMS anxiety-exhibiting mice does not repress CRHR expression when YY1 expression is increased (Sotnikov et al., 2014).