This notion was further corroborated in qRT-PCR and FACS validations, which confirmed the control of S100A8, S100A9, ITGAX, and IRF5 by PIRAT and regulation of these factors during COVID-19 (Fig. 5 D–F, and G and SI Appendix, Fig. S11 E and F). The gene discussed is S100A9; the disease is COVID-19.