When restricting the analysis to mRNAs up-regulated twofold or greater in monocytes during COVID-19 (Figs. 2B and 3 F–H and SI Appendix, Fig. S6F), the same dichotomy as in Fig. 3D was observed, with LUCAT1 deficiency lifting the expression of STAT-downstream genes (e.g., CXCR4 and NAMPT) and reducing classic proinflammatory marker expression (e.g., CXCL2 and CXCL8) (Fig. 3F and SI Appendix, Fig. S7A). This evidence concerns the gene CXCL2 and COVID-19.