Certain tumour molecular characteristics, such as CpG island methylator phenotype (CIMP), microsatellite instability (MSI) and somatic mutations in BRAF and KRAS, have been widely investigated with regard to the heterogeneity of diet and CRC association.14, 15, 16, 17, 18, 19, 20, 21. This evidence concerns the gene KRAS and colorectal carcinoma.