Certain tumour molecular characteristics, such as CpG island methylator phenotype (CIMP), microsatellite instability (MSI) and somatic mutations in BRAF and KRAS, have been widely investigated with regard to the heterogeneity of diet and CRC association.14, 15, 16, 17, 18, 19, 20, 21. The gene discussed is BRAF; the disease is colorectal carcinoma.