In macrophages cocultured with Adam17–/– 4T1 (Figure 2F) or E0771 (Figure 2G) breast cancer cells, we found significantly lower expression of CD163 and/or CD206 in at least 1 of 2 Adam17–/– clones, as compared with macrophages cocultured with WT cancer cells. This evidence concerns the gene MRC1 and breast cancer.