A focused analysis on key genes in FA metabolism revealed that fatty acid binding protein 1 (FABP1), carnitine palmitoyltransferase 2 (CPT2), and acyl-CoA synthetase medium chain family member 5 (ACSM5) expression was progressively reduced along the transition to CKD, whereas the expression of peroxisome proliferator–activated receptor gamma (PPARG), carnitine palmitoyltransferase 1A (CPT1A), and acyl-CoA synthetase long chain family member 4 and 5 (ACSL4 and ACSL5) increased along the same trajectory (Figure 2A and Supplemental Figure 2). Here, ACSL5 is linked to chronic kidney disease.