We examined public repositories pertaining to the transcriptome of mRNA isolated from tubules of diabetic mice and whole-kidney tissue from a transgenic mouse model expressing mutant uromodulin (UmodC147W/+) (NCBI Gene Expression Omnibus [GEO] database accession no. GSE30122 and GSE102566, respectively) and found that expression of this set of FA-related genes had similar trends to that observed in the progression after IRI in the 2 CKD models: Cpt2 and Acsm5 were significantly downregulated in CKD, whereas Acsl4 and Acsl5 were upregulated (Figure 4, B and C). The gene discussed is ACSL4; the disease is chronic kidney disease.