Furthermore, VEGFR1-expressing melanoma cells have been shown to be more invasive compared with melanoma cells that do not express VEGFR1, and the blockade of VEGFR1 using a specific monoclonal antibody reduces VEGF‐A- and PlGF-inducible extracellular matrix invasion (Hennequin et al. 1999). Here, FLT1 is linked to melanoma.