Upon infection, various cardiac-resident cells, such as cardiomyocytes, endothelial cells, mast cells, phagocytes, and fibroblasts, secrete cytokines IL-1β, and IL-18 [7, 10], contributing to acute inflammation, and treatment with IL-1β could break the resistance of C57Bl/6 (H‐2b) mice to viral infection [43]. Here, IL18 is linked to viral infectious disease.