In contrast, those of APC, CD45RA+ CCR7+ naive CD4+ T cells (CD4Tn), CXCR5+ IgD+ CD27+ non-switched memory B cell (CXCR5+ NSMB), and CXCR5+ IgD− CD27+ switched memory B cell (CXCR5+ SMB) were depleted significantly in patients with new-onset SLE compared to HDs (median: APC SLE 0.692%, HD 2.160%, P = 0.0015; CD4Tn SLE 10.395%, HD 16.524%, P = 0.0007; CXCR5+ NSMB 0.117%, HD 0.205%, P = 0.0309; CXCR5+ SMB SLE 0.404%, HD 0.807%, P = 0.0149). This evidence concerns the gene CD4 and systemic lupus erythematosus.