The proliferative activity of CD45RA+ CCR7− CD8+ T cells (CD8Traem), CD4Tn, CXCR3+ t-bet+ type 1 helper CD4+ T cells (CXCR3Th1), CXCR5+ IgD+ CD27− naive B cell (CXCR5+ nB), and PC slightly increased in patients with new-onset SLE (median: CD8Traem SLE 0.317%, HD 0.121%, P = 0.0131; CD4Tn SLE 0.148%, HD 0.243%, P = 0.0044; CXCR3Th1 SLE 0.048, HD 0.024%, P = 0.0389; CXCR5+ nB SLE 0.174%, HD 0.071%, P = 0.0101; PC SLE 0.023%, HD 0.005, P = 0.0021). Here, CD27 is linked to systemic lupus erythematosus.