CFTR and autosomal dominant polycystic kidney disease: Increased chloride secretion due to enhanced CFTR activity is associated with pathologies such as cholera-induced enterotoxigenesis diarrhoea (Field et al., 1972), autosomal dominant polycystic kidney disease (ADPKD), which presents with enlarged cysts (Davidow et al., 1996), and hyperchloremia due to kidney dysfunction.