A neuropathological feature shared by most common neurodegenerative diseases includes the aggregation or deposition of certain proteins in neurons or extracellular spaces, which is often termed as “proteopathies.” The primary hallmarks of AD pathology are amyloid beta Aβ-containing plaques and tau-containing neurofibrillary tangles [4]. The gene discussed is MAPT; the disease is neurodegenerative disease.