Using CSF measurements of A β 42, tau, and phospho-tau, the AD pattern was diagnosed with a sensitivity of 87% and a specificity of 83%. Potential synaptic biomarkers identified: Apo-J, chromogranin A, phospholemman, synaptic protein-like proSAAS and neuronal secretory protein VGF. This evidence concerns the gene CHGA and Alzheimer disease.