In our study, we used as an antigen human aortic α-elastin, glycated in vitro, to determine the serum levels of IgM and IgG autoantibodies to AGEs of vascular elastin (anti-AGE EL IgM antibodies and anti-AGE EL IgG antibodies) in hypertensive patients with T2D. This evidence concerns the gene CD40LG and type 2 diabetes mellitus.