Because anti-CD22 mAbs can target and suppress matured B cells, their indications have been further expanded for the treatment of rheumatoid arthritis (RA), systemic lupus erythematous (SLE), etc. Therefore, it is urgently necessary to develop consistent and reliable protocols for quality control (QC) analysis of anti-CD22 mAbs and derivatives during antibody production or clinical studies [12,20]. This evidence concerns the gene CD22 and systemic lupus erythematosus.