An association of MSA with genetic variants in COQ2, SNCA, MAPT, and PRNP had been discussed.16–20,39 However, these genes have not been convincingly confirmed in other candidate gene studies and have not been associated in a previous MSA GWAS.21 This preceding GWAS analyzed 918 mostly clinical cases and 3864 controls. Here, PRNP is linked to multiple system atrophy.