The role of tumor-infiltrating B cells was studied in ovarian, lung, breast, and cervical cancers: at the tumor site, B lymphocytes can function as antigen-presenting cells to facilitate the persistence of CD8+ T lymphocytes for long periods, improve T lymphocyte responses by producing antibodies, produce cytokines to promote the organization of local lymphoid structure and change the relationship between Th1, Th2 cells.31,42,43. This evidence concerns the gene CD8A and neoplasm.