SCN5A and Brugada syndrome: Seemingly, this is supported by other studies which have found that p.His558Arg variant is more frequent in patients with Brugada syndrome (Matsumura et al., 2017) or Lone atrial fibrillation (Chen et al., 2011; Chen et al., 2007), among whom no additional missense or splice site deleterious variants in SCN5A were detected in comparison to controls.