Likewise, RA patients showed significant higher levels of both, pathogenic (CD4+CD183+IL-17+IL-22+CD243+CD161+IFN-γ+IL-10−) (p < 0.005, Figure 2(b)) and nonpathogenic (CD4+CD183+IL-17+IL-22−CD243−CD161−IFN-γ−IL-10+) (p < 0.05, Figure 2(c)) Th17 lymphocytes, compared to healthy controls. This evidence concerns the gene CD4 and rheumatoid arthritis.