Moreover, female mice carrying the transgene of FGF3 cDNA under the control of MMTV LTR sequence developed pronounced mammary gland hyperplasia with a large amount of epithelial tissue in mammary glands, whereas male mice expressing it in the prostate developed benign prostatic hyperplasia (Muller et al., 1990). Here, FGF3 is linked to benign prostatic hyperplasia.