Despite these limitations, the present study is the most extensive study to date on the association of TP53 rs1042522 C>G polymorphism with glioma risk in Chinese children, and further studies on the susceptibility of TP53 rs1042522 C>G polymorphism may provide new insights into the etiology of glioma, which could be necessary for providing more appropriate treatment for specific populations. The gene discussed is TP53; the disease is glioma.