TP53 and cancer: Significant mutations in TP53 are present in cells of several cancer types, such as ovarian plasmacytoid cystic adenocarcinoma (95%), small cell lung cancer (90%), carcinoma with characteristic lesions of esophageal squamous cell carcinoma (84%), pancreatic ductal adenocarcinoma (80%), and lung squamous cell carcinoma (79%) [8–11].