TP53 and Nephroblastoma: Of which, TP53 Pro/Pro genotype was associated with increased susceptibility to acute lymphoblastic leukemia in Caucasian children [48], TP53 rs1042522 CG/GG genotype had a significantly increased risk of Wilms tumor in children under 18 months of age [49], and TP53 rs1042522 CG/GG genotype was associated with reduced susceptibility to neuroblastoma [50].