Escher et al. reported that factor VIII, as well as VWF activity and antigen, were massively elevated in a consecutive series of five COVID-19 cases with severe diseases admitted to ICU (33–35), whereas ADAMTS13 activity was normal in three cases, ruling out the possibility of thrombotic thrombocytopenic purpura in these cases. This evidence concerns the gene VWF and thrombotic thrombocytopenic purpura.