Consistent with this notion, the mutant IDH1 (ivosidenib) and IDH2 (enasidenib) protein inhibitors have been initially approved by the U.S. food and drug administration (FDA) for relapsed/refractory acute myeloid leukemia (AML)-bearing IDH1 and IDH2 mutations (35). The gene discussed is IDH1; the disease is acute myeloid leukemia.