In this study, we have investigated the role of different genetic polymorphisms viz. CYP1A1 T>C (rs4646903), CYP1A1 A>G (rs1048943), CYP2E1 T>A (rs6413432), RAD51 G>C (rs1801320), XRCC1 G>A (rs25487), XRCC2 G>A (rs3218536) and XRCC3 C>T (rs861539) in the treatment outcome of cisplatin based chemoradiation in cervical cancer patients. The gene discussed is XRCC1; the disease is cervical cancer.