CARD8 and lung adenocarcinoma: Further, multivariate Cox regression analysis suggested that CARD8-AS1 expression (p = 0.022) and TNM stage (p = 0.023) were independent risk factors associated with survival, which implied that CARD8-AS1 expression might be an independent prognostic risk factor associated with the overall survival of patients with lung adenocarcinoma (Supplementary Table S1).