Nonetheless, there was not only a trend toward an increase in the total number of P18-I10+ CD8+ T cells in tumour-bearing mice treated with the anti-CD25 Ab, although not statistically significant (p=0.0594), but there was also a significant increase in the frequency of P18-I10+ cells among CD8+ T cells in these mice (Figures 2(b) and 2(c)). The gene discussed is CD8A; the disease is neoplasm.