AKT1 and polycystic ovary syndrome: In addition, it is reported that Guizhi Fuling Wan (GFW) inhibited GCs' autophagy by activating the phosphatidylinositol-3-Kinase (PI3K)/Protein Kinase B (AKT)/mammalian Target of Rapamycin (mTOR) pathway and alleviated ovulation disorder in PCOS-IR rats [15].