To determine the role of AdipoR1 in the effects of Schisandrin A in model of DN, we regulated the expression of AdipoR1 in mice with DN by Schisandrin A. Sh-AdipoR1 reduced AdipoR1, p-AMPK, Nrf2, HO-1, and SOD2 protein expressions in renal tissue of mice with DN by treated with Schisandrin A (Figures 9(a) and 9(b)). This evidence concerns the gene SOD2 and liver dysplastic nodule.