Additionally, AdipoR1 agonist decreased glomerulus injury and blood glucose, promoted body weight, heightened kidney/body weight and serum creatinine, reduced urea nitrogen and urinary albumin levels, induced E-cadherin mRNA expression, and suppressed periostin mRNA expression in mice with DN by treated with Schisandrin A (Figures 9(c)–9(l)). Here, ADIPOR1 is linked to liver dysplastic nodule.