Using the “rms” package (version 6.2-0) in R (version 4.0.2), a nomogram model based on the 3 specific genes (CARTPT, EPHA5, and SERPINA3) was constructed to predict the risk of Alzheimer's disease (Figure 10(a); GSE122063). This evidence concerns the gene SERPINA3 and early-onset autosomal dominant Alzheimer disease.