LRRK2 and Parkinson disease: However, in Parkinson’s-related Drosophila model, furin 1 has been found to be highly concentrated in TH-positive DA neurons [265], and furin 1 is translationally regulated by leucine-rich repeat kinase 2 (LRRK2) and involved in the impairment of synaptic plasticity and neurodegeneration [266].