The level of BRI2 containing the BRICHOS domain is increased in the hippocampus of early-stage AD patients, whereas the level of the BRI2-APP complex is decreased, accompanied by a decrease of furin, indicating that the aberrant processing of BRI2 may promote its deposition and affect its function in halting Aβ production and aggregation [212]. Here, ITM2B is linked to Alzheimer disease.