We identified three evolutionary paths of gene mutations that could drive PTC progression across pathological stages: (i) recurrently mutated genes in all the stages, with BRAF driver gene showing a dominant role across all stages; (ii) some genes (NRAS and TG) mostly mutated in the early stages while disappearing in the advanced stages; (iii) other mutated genes (TTN, MUC16 and HRAS) emerged dominantly in advanced stages, thus suggesting their impact in the aggressive phenotype of this tumor. This evidence concerns the gene HRAS and neoplasm.