By integrating analyses, we found that the levels of Tregs, myeloid dendritic cells, monocytes and cancer-associated fibroblasts in the high-risk group were higher than those in the low-risk group, while the levels of neutrophils, M1 macrophages, NK cells, CD8 + , CD4 + T cells, and B cells were significantly negatively correlated with the risk of signature. This evidence concerns the gene CD4 and cancer.