An analysis of the Dapagliflozin Effect on Cardiovascular Events–Thrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) trial with the SGLT2 inhibitor dapagliflozin showed a reduction of new and recurrent AF and atrial flutter events [131]. This evidence concerns the gene SLC5A2 and atrial fibrillation.