As shown in Fig. 3E, the migration ability of MDA-MB-453 cells was increased upon stimulation with conditioned supernatants from circWWC3-overexpressed breast cancer medium-stimulated THP-1 cells, whereas IL-4 neutralizing antibody could block the increase of conditioned supernatants-induced migration of MDA-MB-453 cells. Here, IL4 is linked to breast carcinoma.