After being cultured with breast cancer MDA-MB-453 cell-conditioned medium, macrophages were inclined to the M2 phenotype (IL-10 high, TGF-β high, CD163 high, CCL-17 high, CCL-22 high) in the circWWC3-transfected group as compared to the control group (Fig. 2E and G). The gene discussed is CCL22; the disease is breast carcinoma.