Generally, M1 polarized macrophages can express high-level pro-inflammatory cytokines to eliminate tumor cells, whereas M2 polarized macrophages are characterized by secreting a large number of anti-inflammatory cytokines, growth factors, inhibitory molecules such as PD-L1 and PD-L2, to promote tumor cell progression [3–6]. This evidence concerns the gene PDCD1LG2 and neoplasm.