Our data showed that GRK3 OE in MKN45 cells significantly promoted PC measured by bioluminescence weekly, while LD2 treatment significantly reversed PC in GRK3 OE group (Supplemental Fig. 9) indicating that CRK3 is critical for peritoneal metastases and LD2 suppressed PC induced by GRK3 OE. The gene discussed is GRK3; the disease is pachyonychia congenita.