To explore the expression of hepatic senescence markers (p21, p16 and SA-β-Gal), BMP4 and GREM1 within specific cell populations, we examined publicly available single-cell RNA sequencing (RNA-seq) data of healthy and cirrhotic human livers (which includes one patient with NAFLD)30. The gene discussed is GREM1; the disease is metabolic dysfunction-associated steatotic liver disease.