Prediction models for NAFLD/NASH, shown in Fig. 7a, revealed that the strongest features were liver senescence-associated SA-β-Gal, p16 and visceral adipose tissue GREM1. Logistic regression indicated that SA-β-Gal (odds ratio, 23.1; 95% confidence interval (CI), 1.56 to 1,323.0) and visceral GREM1 (odds ratio, 12.7; 95% CI, 2.79 to 175.0) were significant predictors for NAFLD/NASH (Fig. 7a). This evidence concerns the gene CDKN2A and metabolic dysfunction-associated steatohepatitis.