Other known genes upregulated by GREM1 include genes associated with hyperglycemia (DUSP639), NAFLD/NASH (FABP140,41, LYZ42 and TP53INP143), liver fibrosis (CTHRC144) and hepatocellular carcinoma (LPAR645 and CCL1546) (Supplementary Table 3). The gene discussed is GREM1; the disease is metabolic dysfunction-associated steatotic liver disease.