Moreover, genes involved in hepatic fibrosis (that is, TGFβ1, COL1A1 and αSMA) were markedly increased in individuals with NASH compared with lean individuals or those with NAFLD (Fig. 3a) and were also positively correlated with senescence markers (Fig. 3b). The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatohepatitis.