In line with these notions, delivery of oestrogen via the GLP-1RA used here improves body weight, glucose metabolism and dyslipidaemia in DIO mice with greater efficacy relative to treatment with the GLP-1RA or oestrogen alone and without detrimental oestrogen effects in GLP-1R negative uterus or breast tissue23. This evidence concerns the gene GLP1R and inherited lipid metabolism disorder.