CDKN2A and neoplasm: By mapping both KRAS and CDKN2A mutations, we identified several cells in the ADM_tumor population with either a KRAS mutation (n = 1) or CDKN2A mutation (n = 7), although this was not as widespread as the predicted PanIN populations (KRAS: 23 cells; CDKN2A: 163 cells) (Fig. 4g,h and Supplementary Data 3).