We analyzed TIGIT and NECTIN expression of individual samples and observed high expression of all NECTIN receptors in tumor cells and TIGIT in Tregs and exhausted T cells, and noted substantial heterogeneity across cases, particularly in TIGIT expression in exhausted T cells and in NECTIN1 and NECTIN3 expression in tumor cells (Fig. 8d). The gene discussed is TIGIT; the disease is neoplasm.