SOCS2 and hepatocellular carcinoma: To determine whether SOCS2 directly mediated the prognosis of HCC after radiotherapy, we randomly selected appropriate tumor tissues from 12 radiosensitive patients and 12 radioresistant patients of HCC for immunofluorescence, and found that radioresistant tissues exhibited lower SOCS2 expression (Fig. 1I; Fig. S1E).