Furthermore, the survival fraction of SOCS2-ΔSH2 group had no significant difference in comparison with its negative control but significantly higher than that of SOCS2-WT group (Fig. 6G, H), implying that SOCS2 exerts a radiosensitization effect in HCC cells due to its SH2-structural domain. This evidence concerns the gene SOCS2 and hepatocellular carcinoma.