APOE and Alzheimer disease: The lack of statistically significant differences between the two groups can be explained as follows: (1) Aß status is an overlapping and even more relevant factor in AD-related biomarkers than is the APOE4 allele, and (2) the age difference between the Aß+ APOE4 carrier group and Aß+ APOE4 non-carrier group should be considered because aging is an important factor in AD-related biomarkers28–30.