Lee and colleagues showed in a cerebral ischemia model (MCAO) in mice the neuroprotective effects of the peptide AT2 agonist CGP42112 with reduced infarct volumes, while treatment with the non-peptide C21 failed to show protective properties and had no effect on the neuronal survival67 in an in vitro glucose deprivation model. This evidence concerns the gene AGTR2 and Cerebral ischemia.