Assessment of mRNA expression of cytokine/chemokine and their associated genes showed that the CeD-dominated cluster C0 cells differentially express higher levels of IL16, IL18BP, CCL5, CCL20 and IFNG and receptors IL18R1, IL10RB, CCR9, CXCR6, IFNAR2, TNFRSF1B, TNFRSF17 and TNFRSF9. Interestingly we found that IL32, which was highly expressed in CeD-associated CD4+ T cells, is also upregulated in cluster C0 cells suggesting a potential role in the course of the disease. This evidence concerns the gene IL18R1 and cranioectodermal dysplasia.