In the case of the developing fly wing, JNK-driven expression of Wg and Wnt6 induces compensatory proliferation and wing regeneration upon tissue injury (above results and ref. 13), and JNK-driven expression of Wg in tissues subjected to chromosomal instability (CIN)—a high rate in the gain or loss of chromosomes during mitosis and a hallmark or most solid tumours in humans—contributes to the production of tumour-like overgrowths upon additional blockage of the apoptotic pathway36,37. This evidence concerns the gene MAPK8 and neoplasm.