In the multivariable logistic regression model using HCDR as the comparator, PCDR showed and increased risk of failing to achieve IFN-γ > 12 pg/mL, after adjusting for the main identified confounders (age, time from HIV diagnosis, CD4 nadir, HIV-RNA at the time of third dose, days from the date of 2nd dose, vaccine sequence and concomitant cancer), although not statistically significant [2.48 (0.29, 21.56); p = 0.41] (Table 4). This evidence concerns the gene IFNG and cancer.