SOCS3, by virtue of its function of STAT3 signalling suppressor may also provide an anti-fibrotic contribution, as STAT3 promotes liver fibrosis [26], and increased gene expression of the anti-fibrotic fibronectin type III domain containing 5 (Fndc5, also known as irisin) was observed in the KD group [27] (Figure 7). This evidence concerns the gene FNDC5 and Hepatic fibrosis.